DEXAMETHASONE ENHANCES GLUTAMINE SYNTHETASE ACTIVITY AND REDUCES N-METHYL-D-ASPARTATE NEUROTOXICITY IN MIXED CULTURES OF NEURONS AND ASTROCYTES

Dexamethasone enhances glutamine synthetase activity and reduces N-methyl-D-aspartate neurotoxicity in mixed cultures of neurons and astrocytes

Astrocytes are claimed to protect neurons against excitotoxicity by clearing glutamate from the extracellular space and rapidly converting it into glutamine.Glutamine, is then released into the extracellular medium, taken Collections up by neurons and transformed back into glutamate which is then stored into synaptic vesicles.Glutamine synthetase (

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Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor

The majority of gastrointestinal stromal tumors (GIST) harbor an activating mutation in either the KIT or PDGFRA receptor tyrosine kinases.Approval of imatinib, a KIT/PDGFRA AVENAFORCE tyrosine kinase inhibitor (TKI), meaningfully improved the treatment of advanced GIST.Other TKIs subsequently gained approval: sunitinib as a second-line therapy and

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ULTRASONOGRAFI UNTUK PREDIKSI LASERASI PARENKIM GINJAL DAN HEMATOMA PERIRENAL PADA PASIEN TRAUMA TUMPUL ABDOMEN DENGAN KECURIGAAN TRAUMA GINJAL

Objective: To evaluate the sensitivity and the specificity of the ultrasound in predicting renal parenchyma laceration and perirenal hematoma in patients with abdominal blunt trauma with suspicion of renal trauma, as confirmed by operative findings in the explorative laparotomy.Material & methods: From March 2005 to March Drawer Storage 2006, we fo

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Cultural Identity in International Relations: Analysis of the Concept of Polewali Mandar International Folk and Art Festival (PIFAF) in West Sulawesi Through Three Principles of Cultural Diplomacy

This journal aims to analyze the role of national identities in international relations through research on the Polewali Mandar International PEPTIDES Folk & Art Festival (PIFAF), which is held in Barat Island.The current study makes use of a qualitative methodology and focuses on three principles of diplomacy in the realm of business, namely, mutu

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